A REVIEW ON EPIDEMIOLOGY, PATHOGENESIS AND TREATMENT OF LEPTOSPIROSIS

Leptospirosis is a zoonotic disease, it arises worldwide but most frequent in tropical and subtropical zone. It one of the notifiable treatable disease. plague caused by species bacteria called Leptospira shed into nature via urine infected animals. Rats are recurrent source human sepsis. Rivers assumption to be predominant risk factor for transmission disease humans. possesses an extensive variation mechanisms that allow them avoid host immune system cause infection. The infection extremely vast ranging from subclinical multi organ with elevated mortality. frequently mild can terminal, likely serious alignment form known as Weils easily steer death. mingling renal failure, hemorrhage jaundice affection pattern associated critical leptospirosis. accumulating problem superficially existing co-infections various unrelated diseases, including malaria dengue. Laboratory diagnostic tests not always accessible usually diagnosis executed enzyme linked immunosorbent assay (ELISA) serology microscopic agglutination test, rapid test also feasible. MAT (microscopic test) Gold standard. Serological used leptospirois. carcinogenesis mechanism cell membrane injuries which take place mainly due occupancy leptospirosis along their antigen tissues many molecules hand out ability leptospira invade, colonize adhere. In cases antibiotics preferred reduce symptoms